Based on an accurate analysis of information available in specialized literature, and using proprietary selection instruments, Genalta has developed a series of SNP panels able to provide overall indications about the subject’s susceptibility to a variety of complex diseases socially relevant in the western world, and particularly in Italy. The panels provide information on disorders related specifically to the osteo-skeletal system (osteoporosis), cardiovascular system (dyslipidemia as a predisposing condition, myocardial infarction), glucose metabolism (type 2 diabetes), free radical damage prevention/reaction processes (oncogenesis), and neurodegenerative diseases.
- Bone integrity panels
- Cardiovascular panels
- Lipid metabolism panel
- Oxidant susceptibility panel
- Neurodegenerative disease susceptibility panel
- List of centres
BONE INTEGRITY PANELS
Osteoporosis is a multi-factor condition characterized by Bone Mineral Density (BMD) reduction and deterioration of the bone microstructure, the combination of which predisposes to a higher susceptibility to fracture.
The effects of a genetic predisposition to osteoporosis can therefore be opposed through the use of nutritional supplements to increase the intake of elements that contribute to bone formation and consolidation.
Genalta has developed an osteoporosis-specific predictive test, consisting of an analysis of as many as 12 SNPs all related to a person’s predisposition to develop this major disorder. The test can be performed by analyzing the 12 SNPs all in one batch or in two different panels, each composed of 6 SNPs
CARDIOVASCULAR PANELS
The health of the cardiovascular system depends on a good balance between environment, diet and genetic factors. An important role is played by the genes that regulate cholesterol levels, discussed in the section above. Another key genetic factor is related to homocysteine levels. Recent studies have demonstrated that this amino acid is involved in the development of cardiovascular diseases.
A person’s predisposition to cardiovascular diseases can be assessed through a specific genetic test developed by Genalta. Test results may suggest the adoption of appropriate and timely preventive measures, including changes in habits and lifestyle.
Two panel formats are available, a 4-SNP panel and a 6-SNP panel.
LIPID METABOLISM PANEL
Normal lipid transport in the bloodstream is essential to prevent blood vessel damage. Lipids are transported in the bloodstream through lipoprotein particles of different types (VLDL, LDL, HDL) depending on the different amount and quality of fat and protein they contain.
A higher LDL level is a risk factor for cardiovascular diseases. Lipoprotein levels (and therefore lipid levels and particularly LDL particles) increase with age.
An increase in LDL lipoproteins may lead to hyerlipoproteinemia and heighten the risk of atherosclerosis, myocardial infarction, and strokes. At the same time, a strong increase in fat acid levels may cause lipids to become damaged or oxidized, which may result in lower efficiency of the immune system. Variations in the genes analyzed by this panel may impact normal fat metabolism and the transport of lipids in the bloodstream. Thus, once we know how our genes behave through these test results, we may adjust our diet and modify our habits as necessary. Two panel formats are available, a 4-SNP panel and a 6-SNP panel.
OXIDANT SUSCEPTIBILITY PANEL
Oxygen is a vital element – however, it also creates highly reactive and potentially dangerous molecules called free radicals. Free radicals are normally produced by our body during energy processes, but an excessive buildup of these molecules may damage cell DNA, proteins and membranes. The result is a condition called oxidation stress, which is associated with a variety of common disorders including heart diseases, chronic inflammations and tumor transformation, as well as aging process acceleration. To oppose the effects of free radicals, our body has activated protective mechanisms through certain genes that produce antioxidant enzymes, which neutralize highly reactive molecules.
This panel analyzes the variations of 3 of these genes that produce important proteins, whose task is to protect our body from oxidant attacks. If these genes are found to be less active than normal, they can be supported with a targeted intake of antioxidants in the diet or through nutraceutical formulas.
NEURODEGENERATIVE DISEASE SUSCEPTIBILITY PANEL
Approximately 5% of the Italian population develops neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, etc.).
Advances are being made in scientific research for the treatment and prevention of these conditions. It has been demonstrated that stronger endogenous cell defense mechanisms, through the use of nutritional and pharmaceutical antioxidants, may represent an innovative approach. New, more powerful antioxidants available today may assist in the timely, ongoing prevention of these diseases, reducing the risk of their occurring.
In this perspective, being aware of one's genetic predisposition to these conditions may be extremely useful. To this end, Genalta has developed a specific panel to measure the correct functioning of 5 genes associated with Alzheimer’s disease and Parkinson’s disease.
LIST OF CENTRES
Studio Medico Dott.ssa Liane Maria Ledwon
Via Roma, 6
Firenze
Tel: 055 213395
Fax: 055 213361
E mail:
Studio Medico Dott.ssa Ferraro
Via Nazionale 35
Firenze
Tel: 0577/817693
Fax:
E-mail: Fiafer@yahoo.com
Ambulatorio Bios
Corso Statuto, 41/b Area Besio
Mondovi (CN)
Tel: 0174 40 336
Fax: 0174 30 40 337
E-mail: info@ambulatoriobios.it
ISTITUTO di MEDICINA del BENESSERE S.r.l
Via Lorenzo Tabellione, 1
San Marino
Tel: 0549/905831
Fax: 0549 970175
E-mail: info@exclusiveme.com
Amici Antiage
Via Salaria 221 - 00198 Roma
Roma
Tel: 06 85358273
Fax: 06 85355344
E-mail: segreteria@amiciantiage.eu
Ricerche cliniche Prof. Manfredo Fanfani
Piazza della Indipendenza, 18/b - 50129 Firenze
Firenze
Tel: 055/4970.1
Fax: 055/4970284
E-mail: info@istitutofanfani.it